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Why Minimal Guidance During Instruction Does Not Work: An Analysis of the Failure of Constructivist, Discovery, Problem-Based, Experiential, and Inquiry-Based Teaching
Evidence for the superiority of guided instruction is explained in the context of our knowledge of human cognitive architecture, expert–novice differences, and cognitive load. A...
A Robust, Simple Genotyping-by-Sequencing (GBS) Approach for High Diversity Species
Advances in next generation technologies have driven the costs of DNA sequencing down to the point that genotyping-by-sequencing (GBS) is now feasible for high diversity, large ...
Beyond Cholesterol
IT is now well established that hypercholesterolemia is an important cause of coronary heart disease, and clinical intervention studies have demonstrated the therapeutic value o...
Functional connectivity in the resting brain: A network analysis of the default mode hypothesis
Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show grea...
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection
BACKGROUND Treatment with peginterferon alfa-2a alone produces significantly higher sustained virologic responses than treatment with interferon alfa-2a alone in patients with c...
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
In patients with metastatic pancreatic adenocarcinoma, nab-paclitaxel plus gemcitabine significantly improved overall survival, progression-free survival, and response rate, but...
First Case of 2019 Novel Coronavirus in the United States
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCo...
Core capabilities and core rigidities: A paradox in managing new product development
This paper examines the nature of the core capabilities of a firm, focusing in particular on their interaction with new product and process development projects. Two new concept...
A Global Map of Human Impact on Marine Ecosystems
The management and conservation of the world's oceans require synthesis of spatial data on the distribution and intensity of human activities and the overlap of their impacts on...
Governmentality: power and rule in modern society
Introduction to the Second Edition Basic Concepts and Themes Government and Governmentality An Analytics of Government Analyzing Regimes of Government Genealogy and Governmental...