An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
The mRNA-1273 vaccine induced anti-SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified. These findings support further develop...
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Transcriptional Regulatory Networks in <i>Saccharomyces cerevisiae</i>
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as m...
RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays
Ultra-high-throughput sequencing is emerging as an attractive alternative to microarrays for genotyping, analysis of methylation patterns, and identification of transcription fa...
Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015
In international surveys, although there is uncertainty in some estimates, the rate of elevated SBP (≥110-115 and ≥140 mm Hg) increased substantially between 1990 and 2015, and ...
Evidence-Based Health Policy—Lessons from the Global Burden of Disease Study
The Global Burden of Disease Study, a comprehensive regional and global assessment of mortality and disability from 107 diseases and injuries and 10 risk factors, is an example ...
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
The importance of body fat distribution as a predictor of metabolic aberrations was evaluated in 9 nonobese and 25 obese, apparently healthy women. Plasma glucose and insulin le...
AGE STANDARDIZATION OF RATES: A NEW WHO STANDARD
A recent WHO analysis has revealed the need for a new world standard population (see attached table). This has become particularly pertinent given the rapid and continued declin...
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
Background— Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the vaso...
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...
Tau is a candidate gene for chromosome 17 frontotemporal dementia
Abstract Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP‐17), a recently defined disease entity, is clinically characterized by personality changes sometimes...
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
Little is known about the expression levels or function of micro-RNAs (miRNAs) in normal and neoplastic cells, although it is becoming clear that miRNAs play important roles in ...