Publications

High-frequency network oscillation in the hippocampus

Pyramidal cells in the CA1 hippocampal region displayed transient network oscillations (200 hertz) during behavioral immobility, consummatory behaviors, and slow-wave sleep. Sim...

Cloning and expression of a rat brain L-glutamate transporter

Synaptic transmission of most vertebrate synapses is thought to be terminated by rapid transport of the neurotransmitter into presynaptic nerve terminals or neuroglia. L-Glutama...

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

High-performance calcium sensors for imaging activity in neuronal populations and microcompartments

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipi...

Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer

In heavily pretreated patients with HER2-positive metastatic breast cancer, including those with brain metastases, adding tucatinib to trastuzumab and capecitabine resulted in b...

Long-term Persistence in Use of Statin Therapy in Elderly Patients

Persistence with statin therapy in older patients declines substantially over time, with the greatest drop occurring in the first 6 months of treatment. Despite slightly better ...

Methods

Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys

Abstract Previous studies have shown that the orbital and medial prefrontal cortex (OMPFC) is extensively connected with medial temporal and cingulate limbic structures. In this...

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

Two groups of adult male Munich-Wistar rats and a third group of nondiabetic age-matched and weight-matched normal control rats underwent micropuncture study 1 mo, and morpholog...

Modeling polypharmacy side effects with graph convolutional networks

Abstract Motivation The use of drug combinations, termed polypharmacy, is common to treat patients with complex diseases or co-existing conditions. However, a major consequence ...