RNA-Guided Human Genome Engineering via Cas9
Genome Editing Clustered regularly interspaced short palindromic repeats (CRISPR) function as part of an adaptive immune system in a range of prokaryotes: Invading phage and pla...
Publications
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4,169 publications
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; Clinic...
Enzymatic Determination of Total Serum Cholesterol
Abstract An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent. The method requires no prior treatment of sample and t...
Emerging Photoluminescence in Monolayer MoS<sub>2</sub>
Novel physical phenomena can emerge in low-dimensional nanomaterials. Bulk MoS(2), a prototypical metal dichalcogenide, is an indirect bandgap semiconductor with negligible phot...
The Fluid Mosaic Model of the Structure of Cell Membranes
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions impo...
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
A recent report that 93 per cent of invasive cervical cancers worldwide contain human papillomavirus (HPV) may be an underestimate, due to sample inadequacy or integration event...
THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM
In the past few years several methods have been developed for the analysis of serum lipoproteins.Lindgren, Elliott, and Gofman (1) have utilized the relatively low density of th...
Down-Regulation of Na<sup>+</sup>/K<sup>+</sup>ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
These guidelines have been reviewed and approved by the Maternal Fetal Medicine and Infectious Diseases Committees of the SOGC, and the Council of the SOGC.
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. I...