Publications

An improved Bonferroni procedure for multiple tests of significance

Journal Article An improved Bonferroni procedure for multiple tests of significance Get access R. J. SIMES R. J. SIMES Ludwig Institute for Cancer Research, University of Sydney...

Climate Change and Food Systems

Food systems contribute 19%–29% of global anthropogenic greenhouse gas (GHG) emissions, releasing 9,800–16,900 megatonnes of carbon dioxide equivalent (MtCO 2 e) in 2008. Agricu...

Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study

Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Stroke Network, Health Research Board Ireland, Swedish Research Council, Swedish Heart an...

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Introduction to the recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Background Criteria for the clinical diagnosis of Alzheimer's disease (AD) were established in 1984. A broad consensus now exists that these criteria should be revised to incorp...

Cancer Disparities by Race/Ethnicity and Socioeconomic Status

This article highlights disparities in cancer incidence, mortality, and survival in relation to race/ethnicity, and census data on poverty in the county or census tract of resid...

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

Abstract Too many reports of associations between genetic variants and common cancer sites and other complex diseases are false positives. A major reason for this unfortunate si...

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

A Deep Look Into Our Genes Recent debates have focused on the degree of genetic variation and its impact upon health at the genomic level in humans (see the Perspective by Casal...

Exome sequencing as a tool for Mendelian disease gene discovery

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

In this small study involving older adults, adverse events associated with the mRNA-1273 vaccine were mainly mild or moderate. The 100-μg dose induced higher binding- and neutra...

Overdiagnosis in Cancer

This article summarizes the phenomenon of cancer overdiagnosis-the diagnosis of a "cancer" that would otherwise not go on to cause symptoms or death. We describe the two prerequ...

Structure and Interpretation of Computer Programs

"The Structure and Interpretation of Computer Programs" is the entry-level subject in Computer Science at the Massachusetts Institute of Technology. It is required of all studen...