RNA interference is mediated by 21- and 22-nucleotide RNAs
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in v...
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731 publications
A comparison of event models for naive bayes text classification
Recent work in text classification has used two different first-order probabilistic models for classification, both of which make the naive Bayes assumption. Some use a multi-va...
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
Significance The last decade has seen a rapid expansion of interest in extracellular vesicles (EVs), proposed to mediate cell–cell communication in patho/physiological condition...
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase...
Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with advanced stage disease respond initially but then...
American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults
The American Geriatrics Society (AGS) Beers Criteria® (AGS Beers Criteria®) for Potentially Inappropriate Medication (PIM) Use in Older Adults are widely used by clinicians, edu...
From sensation to cognition
Sensory information undergoes extensive associative elaboration and attentional modulation as it becomes incorporated into the texture of cognition. This process occurs along a ...
The Lancet Commission on global mental health and sustainable development
The Sustainable Development Goals (SDGs) represent an exponential advance from the Millennium Development Goals, with a substantially broader agenda affecting all nations and re...
CAR T cell immunotherapy for human cancer
Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The fie...
The role of short-chain fatty acids in microbiota–gut–brain communication
Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract, are speculated to have a key role in mic...
A Simple Implicit Measure of the Effective Bid‐Ask Spread in an Efficient Market
ABSTRACT In an efficient market, the fundamental value of a security fluctuates randomly. However, trading costs induce negative serial dependence in successive observed market ...
Near optimum error correcting coding and decoding: turbo-codes
This paper presents a new family of convolutional codes, nicknamed turbo-codes, built from a particular concatenation of two recursive systematic codes, linked together by nonun...