Publications
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Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La ...
Numerical Methods for Unconstrained Optimization and Nonlinear Equations
Preface 1. Introduction. Problems to be considered Characteristics of 'real-world' problems Finite-precision arithmetic and measurement of error Exercises 2. Nonlinear Problems ...
Remdesivir for the Treatment of Covid-19 — Final Report
Our data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory trac...
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
Oral bioavailability measurements in rats for over 1100 drug candidates studied at SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze the relati...
Fractional Brownian Motions, Fractional Noises and Applications
Previous article Next article Fractional Brownian Motions, Fractional Noises and ApplicationsBenoit B. Mandelbrot and John W. Van NessBenoit B. Mandelbrot and John W. Van Nessht...
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
tion’, implying that most patients ‘should’ receive a particular action. In contrast, level 2 guidelines are essentially ‘suggestions’ and are deemed to be ‘weak’ or discretiona...
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Cells, the basic units of biological structure and function, vary broadly in type and state. Single-cell genomics can characterize cell identity and function, but limitations of...
Physical Status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee
Anthropometry provides the single most portable, universally applicable, inexpensive and non-invasive technique for assessing the size, proportions, and composition of the human...
Deep Learning Face Attributes in the Wild
Predicting face attributes in the wild is challenging due to complex face variations. We propose a novel deep learning framework for attribute prediction in the wild. It cascade...
The Adaptive Lasso and Its Oracle Properties
The lasso is a popular technique for simultaneous estimation and variable selection. Lasso variable selection has been shown to be consistent under certain conditions. In this w...