Arlene H. Sharpe - Researcher Profile

Publications

7 shown

The B7–CD28 superfamily

Arlene H. Sharpe , Gordon J. Freeman

2002 Nature reviews. Immunology 1660 citations

THE B7 FAMILY REVISITED

Rebecca J. Greenwald , Gordon J. Freeman , Arlene H. Sharpe

▪ Abstract The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways i...

2005 Annual Review of Immunology 2271 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Yvette Latchman , Clive R. Wood , Tatyana Chernova +18 more

2001 Nature Immunology 2901 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol , Frank Borriello , Alain Schweitzer +3 more

1995 Immunity 2862 citations

Defining ‘T cell exhaustion’

Christian U. Blank , W. Nicholas Haining , Werner Held +15 more

2019 Nature reviews. Immunology 1423 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Benoı̂t L. Salomon , Deborah J. Lenschow , Lesley Rhee +4 more

CD28/B7 costimulation has been implicated in the induction and progression of autoimmune diseases. Experimentally induced models of autoimmunity have been shown to be prevented ...

2000 Immunity 2028 citations

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Robert T. Manguso , F. Stephen Hodi , Scott J. Rodig +24 more

2019 Nature Immunology 1853 citations

Frequent Co-Authors

Researcher Info

h-index: 7
Publications: 7
Citations: 14,998
Institution: Brigham and Women's Hospital

External Links

ORCID Profile Google Scholar

Identifiers

ORCID: 0000-0002-9736-2109

Impact Metrics

h-index 7

h-index: Number of publications with at least h citations each.