David R. Mole - Researcher Profile | RDL Research Database

Publications

3 shown

Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein

Matthew E. Cockman , Norma Masson , David R. Mole +7 more

The von Hippel-Lindau tumor suppressor protein (pVHL) has emerged as a key factor in cellular responses to oxygen availability, being required for the oxygen-dependent proteolys...

2000 Journal of Biological Chemistry 1036 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola , David R. Mole , Ya‐Min Tian +10 more

Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by oxygen. In oxygenated and iron replete cells, HIF-α...

2001 Science 5409 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein , Jonathan Gleadle , Luke A. McNeill +17 more

2001 Cell 3296 citations

Frequent Co-Authors

Researcher Info

h-index: 3
Publications: 3
Citations: 9,741
Institution: Centre for Human Genetics

External Links

ORCID Profile Google Scholar

Identifiers

ORCID: 0000-0002-0984-300X

Impact Metrics

h-index 3

h-index: Number of publications with at least h citations each.