Dennis L. Murphy

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

Assessing Clinical Characteristics of the Manic State

The authors found that 11 of the 26 items of the Manic-State Rating Scale characterized common elements of mania in 12 manic-depressive patients and that these items were highly...

Depression, Elation, and Lithium Carbonate Responses in Manic Patient Subgroups

Depressive elements were observed on a quantitative behavioral rating scale during manic episodes in 28 of 30 patients, suggesting that most manic patients manifest a "mixed" ma...

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used upt...

Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice

Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, b...

Genetic perspectives on the serotonin transporter