Graça Raposo

Shedding light on the cell biology of extracellular vesicles

Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which ...

As we wait: coping with an imperfect nomenclature for extracellular vesicles

There is increasing evidence that secreted vesicles play important roles in numerous aspects of biology (e.g. intercellular vesicle traffic, immunity, development, neurobiology ...

Intestinal epithelial cells secrete exosome–like vesicles

Caveolae and sorting in the trans-Golgi network of epithelial cells.

Exosomal-like vesicles are present in human blood plasma

Exosomes are small membrane vesicles (50-90 nm in diameter) secreted by most hematopoietic cells. We provide here the first evidence for the presence of exosomes in vivo, in the...

Exosomes: A Common Pathway for a Specialized Function

Exosomes are membrane vesicles that are released by cells upon fusion of multivesicular bodies with the plasma membrane. Their molecular composition reflects their origin in end...

Extracellular vesicles: Exosomes, microvesicles, and friends

Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. Thes...

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Exosomes are small membrane vesicles, secreted by most cell types from multivesicular endosomes, and thought to play important roles in intercellular communications. Initially d...

Malignant effusions and immunogenic tumour-derived exosomes

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

Abstract We show in this study that human T cells purified from peripheral blood, T cell clones, and Jurkat T cells release microvesicles in the culture medium. These microvesic...

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways

Dendritic cells (DCs) express major histocompatibility complex class II (MHC II) to present peptide antigens to T cells. In immature DCs, which bear low cell surface levels of M...

Drosophila <scp>S2</scp> Cells Secrete Wingless on Exosome‐Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

Wingless acts as a morphogen in Drosophila wing discs, where it specifies cell fates and controls growth several cell diameters away from its site of expression. Thus, despite b...

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

In the 1980s, exosomes were described as vesicles of endosomal origin secreted from reticulocytes. Interest increased around these extracellular vesicles, as they appeared to pa...

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Abstract Exosomes are small membrane vesicles found in cell culture supernatants and in different biological fluids. Exosomes form in a particular population of endosomes, calle...

B lymphocytes secrete antigen-presenting vesicles.

Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major histocompatibility complex [MHC] class II-enriched compartment), that harbors newly synthe...

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Extracellular vesicles shuffling intercellular messages: for good or for bad