Graham R. Bignell - Researcher Profile

Publications

7 shown

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov , Serena Nik‐Zainal , David C. Wedge +67 more

2013 Nature 9767 citations

Mutational Processes Molding the Genomes of 21 Breast Cancers

Serena Nik‐Zainal , Ludmil B. Alexandrov , David C. Wedge +50 more

2012 Cell 1933 citations

The Life History of 21 Breast Cancers

Serena Nik‐Zainal , Peter Van Loo , David C. Wedge +46 more

2012 Cell 1475 citations

A Hypermutation Phenotype and Somatic <i>MSH6</i> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Chris Hunter , Raffaella Smith , Daniel P. Cahill +52 more

Abstract Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylating agent temozolom...

2006 Cancer Research 426 citations

The landscape of cancer genes and mutational processes in breast cancer

Philip J. Stephens , Patrick Tarpey , Helen Davies +59 more

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations, confer clonal selective advantage on cancer cells and are causally implicated in oncog...

2012 Nature 1700 citations

Mutations of the BRAF gene in human cancer

Helen Davies , Graham R. Bignell , Charles Cox +49 more

2002 Nature 10501 citations

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens , Chris Greenman , Beiyuan Fu +29 more

2011 Cell 2368 citations

Frequent Co-Authors

Researcher Info

h-index: 7
Publications: 7
Citations: 28,170
Institution: Wellcome Sanger Institute

External Links

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Impact Metrics

h-index 7

h-index: Number of publications with at least h citations each.