Michael F. Clarke

Prospective identification of tumorigenic breast cancer cells

Breast cancer is the most common malignancy in United States women, accounting for >40,000 deaths each year. These breast tumors are comprised of phenotypically diverse popul...

Stem cells, cancer, and cancer stem cells

Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with eval...

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

Although the existence of mammary stem cells has been suggested by serial transplantation studies in mice, their identification has been hindered by the lack of specific surface...