Figure S1 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>Taselisib and GDC-0077 have increased potency in PIK3CA-mutant cancer cells</p>
Publications
7 shownFigure S4 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>Taselisib depletes mutant p110a protein through ubiquitin and proteasome mechanism in a dose and time dependent manner</p>
Figure S3 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>Taselisib and GDC-0077 induce mutant p110a and not WT p110a degradation</p>
Figure S6 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>RTK activity plays a key role in regulating p110a degradation</p>
Evaluation of Azithromycin-Bicarbonate against Multidrug-Resistant Pathogens in Topical Murine Models of Infection
Multidrug-resistant pulmonary infections pose significant therapeutic challenges as treatment options continue to dwindle in the face of rising antimicrobial resistance. Similar...
Figure S5 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>Taselisib-mediated degradation of mutant p110a occurs preferentially at the plasma membrane.</p>
Figure S2 from RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy
<p>Activity of GDC-0077 in combination with Palbociclib and/ or Fulvestrant</p>
Frequent Co-Authors
Researcher Info
- h-index
- 0
- Publications
- 7
- Citations
- 0
- Institution
- University of Wisconsin–Madison
External Links
Identifiers
- ORCID
- 0000-0002-1127-9970
Impact Metrics
h-index
0
h-index: Number of publications with at least h citations each.