Kun Zhang

A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells

Normal variation in gene expression due to regulatory polymorphisms is often masked by biological and experimental noise. In addition, some regulatory polymorphisms may become a...

Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation

Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome

We describe a DNA sequencing technology in which a commonly available, inexpensive epifluorescence microscope is converted to rapid nonelectrophoretic DNA sequencing automation....

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

Single-nucleus gene expression Identifying the genes expressed at the level of a single cell nucleus can better help us understand the human brain. Blue et al. developed a singl...