Levi A. Garraway

Next-generation characterization of the Cancer Cell Line Encyclopedia

Mutational heterogeneity in cancer and the search for new cancer-associated genes

The landscape of somatic copy-number alteration across human cancers

Melanoma genome sequencing reveals frequent PREX2 mutations

Punctuated Evolution of Prostate Cancer Genomes

Lessons from the Cancer Genome

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to a...

Nuclear factor I/B is an oncogene in small cell lung cancer

Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characte...

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

BRAF mutation predicts sensitivity to MEK inhibition

High-throughput oncogene mutation profiling in human cancer

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

Abstract The classification of human tumors based on molecular criteria offers tremendous clinical potential; however, discerning critical and “druggable” effectors on a large s...

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. Howe...

Clinical Implications of the Cancer Genome

Cancer is a disease of the genome. Most tumors harbor a constellation of structural genomic alterations that may dictate their clinical behavior and treatment response. Whereas ...

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

A detailed understanding of the mechanisms by which tumors acquire resistance to targeted anticancer agents should speed the development of treatment strategies with lasting cli...