An integrated encyclopedia of DNA elements in the human genome
The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) pro...
Publications
6 shownDNase-seq: A High-Resolution Technique for Mapping Active Gene Regulatory Elements across the Genome from Mammalian Cells
INTRODUCTION Identification of active gene regulatory elements is a key to understanding transcriptional control governing biological processes such as cell-type specificity, di...
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells
Regulation of gene transcription in diverse cell types is determined largely by varied sets of cis -elements where transcription factors bind. Here we demonstrate that data from...
Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric disorders. However, understanding the underlying molecular mechanisms remains challenging. R...
The accessible chromatin landscape of the human genome
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, in...
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD), lags be...
Frequent Co-Authors
Researcher Info
- h-index
- 6
- Publications
- 6
- Citations
- 8,832
- Institution
- Duke University
External Links
Identifiers
- ORCID
- 0000-0003-2271-8067
Impact Metrics
h-index
6
h-index: Number of publications with at least h citations each.