Luigi Ferrucci

Chronic inflammation in the etiology of disease across the life span

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome...

Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [ ¹¹ C]PiB

Higher Abeta deposition is associated with greater longitudinal decline in mental status and verbal memory in the preceding years. The differential association for verbal but no...

Blood Pressure Trajectories in the 20 Years Before Death

Mean SBP and DBP decreased for more than a decade before death in patients dying at 60 years and older. These BP decreases are not simply attributable to age, treatment of hyper...

Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication

clinicaltrials.gov Identifier: NCT00106327.

A Short Physical Performance Battery Assessing Lower Extremity Function: Association With Self-Reported Disability and Prediction of Mortality and Nursing Home Admission

This study provides evidence that performance measures can validly characterize older persons across a broad spectrum of lower extremity function. Performance and self-report me...

A reference panel of 64,976 haplotypes for genotype imputation

Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults ha...

Impact of Anemia and Cardiovascular Disease on Frailty Status of Community-Dwelling Older Women: The Women's Health and Aging Studies I and II

In community-dwelling older women, mildly low and low-normal Hb levels were independently associated with increased frailty risk. This risk was synergistically modified by the p...

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individ...

Sarcopenic obesity: definition, cause and consequences

Recognition of obese patients who have associated muscle problems is an essential goal for clinicians. Further research is needed to identify new target for prevention and cure ...

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Common variants at 30 loci contribute to polygenic dyslipidemia

Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report

The discovery of effective interventions to prevent or delay disability in older persons is a public health priority. Most likely to benefit from such interventions are frail in...

Plaque Composition in the Proximal Superficial Femoral Artery and Peripheral Artery Disease Events

The aim of this study was to describe associations of the presence of lipid-rich necrotic core (LRNC) in the proximal superficial femoral artery (SFA) with lower extremity perip...