Manolis Kellis

The GTEx Consortium atlas of genetic regulatory effects across human tissues

The Genotype-Tissue Expression (GTEx) project dissects how genetic variation affects gene expression and splicing.

The NIH Roadmap Epigenomics Mapping Consortium

The Genotype-Tissue Expression (GTEx) project.

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

Integrative annotation of chromatin elements from ENCODE data

The ENCODE Project has generated a wealth of experimental information mapping diverse chromatin properties in several human cell lines. Although each such data track is independ...

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Reliable prediction of regulator targets using 12 <i>Drosophila</i> genomes

Gene expression is regulated pre- and post-transcriptionally via cis -regulatory DNA and RNA motifs. Identification of individual functional instances of such motifs in genome s...

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of <i>Drosophila</i> microRNAs

MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms. We used computational methods to predict miRNAs conserved among Drosophila species and ...

Systematic discovery and characterization of fly microRNAs using 12 <i>Drosophila</i> genomes

MicroRNAs (miRNAs) are short regulatory RNAs that inhibit target genes by complementary binding in 3′ untranslated regions (3′ UTRs). They are one of the most abundant classes o...

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

An integrated encyclopedia of DNA elements in the human genome

The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) pro...

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-seq) has become a valuable and widely used approach for mapping the genomic location of tra...

GENCODE: The reference human genome annotation for The ENCODE Project

The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Sinc...