Timothy F. Cloughesy

Targeted Molecular Therapy of GBM

Major advances in molecular biology, cellular biology and genomics have substantially improved our understanding of cancer. Now, these advances are being translated into therapy...

Molecular Analysis of Glioblastoma: Pathway Profiling and Its Implications for Patient Therapy

Technological advances in the ability to analyze patterns of gene expression and signal transduction pathway activation are improving our understanding of cancer. Previously unr...

Distinct Transcription Profiles of Primary and Secondary Glioblastoma Subgroups

Abstract Glioblastomas are invasive and aggressive tumors of the brain, generally considered to arise from glial cells. A subset of these cancers develops from lower-grade gliom...

Gene Expression Profiling of Gliomas Strongly Predicts Survival

Abstract In current clinical practice, histology-based grading of diffuse infiltrative gliomas is the best predictor of patient survival time. Yet histology provides little insi...

Identification of molecular subtypes of glioblastoma by gene expression profiling

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important adv...

Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

Coexpression of EGFRvIII and PTEN by glioblastoma cells is associated with responsiveness to EGFR kinase inhibitors.