Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Abstract

Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Keywords

Affiliated Institutions

• Brigham and Women's Hospital US
• Centre Oscar Lambret FR
• Université de Lille FR
• LMU Klinikum DE
• Harvard University US
• Mayo Clinic US
• Assistance Publique – Hôpitaux de Paris FR
• University of California, Los Angeles US
• University Hospital Heidelberg DE
• Johns Hopkins Medicine US
• University of Zurich CH
• University of Virginia US
• Sorbonne Université FR
• St James's University Hospital GB
• Yale University US
• Leiden University Medical Center NL
• National Cancer Institute US
• Erasmus MC Cancer Institute NL
• University Hospitals of Cleveland US
• Dana-Farber Brigham Cancer Center US
• Case Western Reserve University US
• Miami Heart Research Institute US
• University School US
• The University of Texas MD Anderson Cancer Center US
• Medisch Centrum Haaglanden NL
• Princess Margaret Cancer Centre CA
• Ludwig-Maximilians-Universität München DE
• National Institutes of Health US
• University of Siena IT
• Centre National de la Recherche Scientifique FR
• New York Hospital Queens US
• German Cancer Research Center DE
• Northwestern University US
• NewYork–Presbyterian Hospital US
• Medical University of Vienna AT
• Inserm FR
• Columbia University US
• Dana-Farber Cancer Institute US
• National Center for Tumor Diseases DE
• University of Leeds GB
• Jackson Laboratory US
• Johns Hopkins University US
• Institut du Cerveau FR
• University of California, San Francisco US
• Memorial Sloan Kettering Cancer Center US
• Heidelberg University DE
• University of Lausanne CH
• Center for Cancer Research US

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