Dana-Farber Brigham Cancer Center

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly d...

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

Overall survival and objective response rates were significantly higher with nivolumab plus ipilimumab than with sunitinib among intermediate- and poor-risk patients with previo...

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

Creation of human tumour cells with defined genetic elements

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

A number of genetic mutations have been identified in human breast cancers, yet the specific combinations of mutations required in concert to form breast carcinoma cells remain ...

CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human an...

Immune Therapy for Cancer

Over the past decade, immune therapy has become a standard treatment for a variety of cancers. Monoclonal antibodies, immune adjuvants, and vaccines against oncogenic viruses ar...

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

The impact of pathology review on treatment recommendations for patients with adenocarcinoma of the prostate