Genome Institute of Singapore

Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

SIFT web server: predicting effects of amino acid substitutions on proteins

The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first introduced in 2001, with a corresponding website t...

An oestrogen-receptor-α-bound human chromatin interactome

Functional metagenomic profiling of nine biomes

RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses

The human gut is known to be a reservoir of a wide variety of microbes, including viruses. Many RNA viruses are known to be associated with gastroenteritis; however, the enteric...

Evolution of the mammalian transcription factor binding repertoire via transposable elements

Identification of lineage-specific innovations in genomic control elements is critical for understanding transcriptional regulatory networks and phenotypic heterogeneity. We ana...

Assemblathon 1: A competitive assessment of de novo short read assembly methods

Low-cost short read sequencing technology has revolutionized genomics, though it is only just becoming practical for the high-quality de novo assembly of a novel large genome. W...

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages