Johns Hopkins Hospital

The Sequence of the Human Genome

A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion bp ...

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic ...

Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design: Thirty-two intern...

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

In patients with severe aortic stenosis who were at low surgical risk, TAVR with a self-expanding supraannular bioprosthesis was noninferior to surgery with respect to the compo...

Clues to the Pathogenesis of Familial Colorectal Cancer

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of spo...

The genomic landscape of hypodiploid acute lymphoblastic leukemia

Differential diagnosis of suspected multiple sclerosis: a consensus approach

Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of diseases that could better explain the clinical and paraclinical findings. A systematic proc...

The Histologic Type and Stage Distribution of Ovarian Carcinomas of Surface Epithelial Origin

Advances over the past decade suggest a need to reassess the distribution of ovarian surface epithelial tumors. A series of 220 consecutive invasive ovarian carcinomas, includin...

PROCESSES OF EXCITATION IN THE DENDRITES AND IN THE SOMA OF SINGLE ISOLATED SENSORY NERVE CELLS OF THE LOBSTER AND CRAYFISH

The stretch receptor organs of Alexandrowicz in lobster and crayfish possess sensory neurons which have their cell bodies in the periphery. The cell bodies send dendrites into a...

Behavioral sexology: Ten cases of genetic male intersexuality with impaired prenatal and pubertal androgenization