Ludwig Cancer Research

Topological domains in mammalian genomes identified by analysis of chromatin interactions

Integrative analysis of 111 reference human epigenomes

The Immunobiology of Cancer Immunosurveillance and Immunoediting

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203–213], the presence of CD3 + tumor-infiltrating lymphocytes (TILs) was found to correlate with improved surviva...

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

The NIH Roadmap Epigenomics Mapping Consortium

Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG...

A high-resolution map of the three-dimensional chromatin interactome in human cells

Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome

A Structural Scaffolding of Intermediate Filaments in Health and Disease

The cytoplasm of animal cells is structured by a scaffolding composed of actin microfilaments, microtubules, and intermediate filaments. Intermediate filaments, so named because...