Oncode Institute

Signatures of mutational processes in human cancer

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants of response to this...

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

The gene-expression profile we studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and hi...

The Human Cell Atlas

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the ...

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

Physical Activity and Breast Cancer

There is evidence for an inverse association between physical activity and breast cancer risk. The evidence is stronger for postmenopausal breast cancer than for premenopausal b...

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

Preoperative chemotherapy in patients with resectable non-small cell lung cancer: results of the MRC LU22/NVALT 2/EORTC 08012 multicentre randomised trial and update of systematic review

Parallel detection of antigen-specific T cell responses by combinatorial encoding of MHC multimers