A bioorthogonal system reveals antitumour immune function of pyroptosis

Qinyang Wang; Yupeng Wang; Jingjin Ding; Chunhong Wang; Xuehan Zhou; Wenqing Gao; Huanwei Huang; Feng Shao; Zhibo Liu

doi:10.1038/s41586-020-2079-1

Keywords

Bioorthogonal chemistryPyroptosisChemistryImmune systemConjugateImmune checkpointInflammasomeCancer researchProgrammed cell deathBiochemistryImmunotherapyBiologyApoptosisImmunologyClick chemistryCombinatorial chemistry

Affiliated Institutions

Related Publications

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot , Eicke Latz , Bernardo S. Franklin

Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immun...

2021 Cellular and Molecular Immunology 1884 citations

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang , Jin Xu , Bo Zhang +6 more

2020 Journal of Hematology & Oncology 1280 citations

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhiwei Zhou , Huabin He , Kun Wang +12 more

Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a fami...

2020 Science 1217 citations

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang , Michael D. Green , Jae Eun Choi +27 more

Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours m...

2019 Nature 2612 citations

Mitochondria as multifaceted regulators of cell death

Florian J. Bock , Stephen W. G. Tait

Through their many and varied metabolic functions, mitochondria power life. Paradoxically, mitochondria also have a central role in apoptotic cell death. Upon induction of mitoc...

2019 Nature Reviews Molecular Cell Biology 2214 citations

Publication Info

Year: 2020
Type: article
Volume: 579
Issue: 7799
Pages: 421-426
Citations: 1005
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

A bioorthogonal system reveals antitumour immune function of pyroptosis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1005

OpenAlex

Cite This

APA Style

                            
                                
                                    Qinyang Wang, 
                                
                                    Yupeng Wang, 
                                
                                    Jingjin Ding
                                
                                et al.
                            
                            (2020). 
                            A bioorthogonal system reveals antitumour immune function of pyroptosis. 
                            Nature
                            , 579
                            (7799)
                            , 421-426.
                            https://doi.org/10.1038/s41586-020-2079-1
                        

Identifiers

DOI: 10.1038/s41586-020-2079-1