National Institute of Biological Sciences, Beijing

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Inflammatory caspases are innate immune receptors for intracellular LPS

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal development. ULK1, a mammali...

The gasdermins, a protein family executing cell death and inflammation

The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell deat...

SARS-CoV-2 and viral sepsis: observations and hypotheses

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a fami...

A bioorthogonal system reveals antitumour immune function of pyroptosis

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

Significance Our analyses uncover general immunogenic activity of bacterial T3SS needle protein and identify human NAIP and mouse NAIP1 as cytosolic innate immune sensors of bac...