Feng Shao

Erratum: Pore-forming activity and structural autoinhibition of the gasdermin family

A bioorthogonal system reveals antitumour immune function of pyroptosis

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Inflammatory caspases are innate immune receptors for intracellular LPS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity

The <scp>NAIP</scp>–<scp>NLRC</scp>4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

Summary Bacterial flagella and type III secretion system (T3 SS ) are evolutionarily related molecular transport machineries. Flagella mediate bacterial motility; the T3 SS deli...

The gasdermins, a protein family executing cell death and inflammation

The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell deat...

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a fami...

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

Significance Our analyses uncover general immunogenic activity of bacterial T3SS needle protein and identify human NAIP and mouse NAIP1 as cytosolic innate immune sensors of bac...