Abstract
Abstract A new measure of the extent of population subdivision as inferred from allele frequencies at microsatellite loci is proposed and tested with computer simulations. This measure, called R(ST), is analogous to Wright's F(ST) in representing the proportion of variation between populations. It differs in taking explicit account of the mutation process at microsatellite loci, for which a generalized stepwise mutation model appears appropriate. Simulations of subdivided populations were carried out to test the performance of R(ST) and F(ST). It was found that, under the generalized stepwise mutation model, R(ST) provides relatively unbiased estimates of migration rates and times of population divergence while F(ST) tends to show too much population similarity, particularly when migration rates are low or divergence times are long [corrected].
Keywords
BiologyMicrosatelliteGeneticsAlleleSubdivisionAllele frequencyMeasure (data warehouse)PopulationPopulation geneticsEvolutionary biologyGeneDemographyGeographyComputer science
MeSH Terms
AllelesBiological EvolutionComputer SimulationDNASatelliteGene FrequencyModelsGeneticPopulation DynamicsStatistics as Topic
Affiliated Institutions
Related Publications
Subtle population structuring within a highly vagile marine invertebrate, the veined squid <i>Loligo forbesi</i>, demonstrated with microsatellite DNA markers
Microsatellite DNA markers were applied for the first time in a population genetic study of a cephalopod and compared with previous estimates of genetic differentiation obtained...
Temporal analysis of archived samples indicates marked genetic changes in declining North Sea cod (<i>Gadus morhua</i>)
Despite increasing evidence that current exploitation rates can contribute to shifts in life-history traits and the collapse of marine fish stocks, few empirical studies have in...
Genetic Distance between Populations
A measure of genetic distance (D) based on the identity of genes between populations is formulated. It is defined as D = -logeI, where I is the normalized identity of genes betw...
<scp>micro</scp>‐<scp>checker</scp>: software for identifying and correcting genotyping errors in microsatellite data
Abstract DNA degradation, low DNA concentrations and primer‐site mutations may result in the incorrect assignment of microsatellite genotypes, potentially biasing population gen...
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
Abstract We describe extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data. Most importantly, we develop methods that all...
Publication Info
- Year
- 1995
- Type
- article
- Volume
- 139
- Issue
- 1
- Pages
- 457-462
- Citations
- 3698
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
3698
OpenAlex
2635
CrossRef
Cite This
Montgomery Slatkin
(1995).
A measure of population subdivision based on microsatellite allele frequencies..
Genetics
, 139
(1)
, 457-462.
https://doi.org/10.1093/genetics/139.1.457
Identifiers
- DOI
- 10.1093/genetics/139.1.457
- PMID
- 7705646
- PMCID
- PMC1206343