A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper; Wim Annaert; Philippe Cupers; Paul Säftig; Katleen Craessaerts; Jeff S. Mumm; Eric H. Schroeter; Vincent Schrijvers; Michael S. Wolfe; William J. Ray; Alison Goate; Raphael Kopan

doi:10.1038/19083

Keywords

PresenilinNotch signaling pathwayAmyloid precursor protein secretaseNotch proteinsCell biologyNotch 1BiologyTransmembrane proteinTransmembrane domainIntracellularAlpha secretaseCleavage (geology)Caenorhabditis elegansGamma secretaseAmyloid precursor proteinSignal transductionReceptorBiochemistryAlzheimer's diseaseGeneDiseaseMedicine

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Publication Info

Year: 1999
Type: article
Volume: 398
Issue: 6727
Pages: 518-522
Citations: 2071
Access: Closed

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APA Style

                            
                                
                                    Bart De Strooper, 
                                
                                    Wim Annaert, 
                                
                                    Philippe Cupers
                                
                                et al.
                            
                            (1999). 
                            A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. 
                            Nature
                            , 398
                            (6727)
                            , 518-522.
                            https://doi.org/10.1038/19083
                        

Identifiers

DOI: 10.1038/19083