Abstract

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon carcinoma model (MCA-38), animals bearing a tumor longer than 26 days develop CD8 + T cells with impaired cytotoxic function, decreased expression of the tumor necrosis factor-α and granzyme B genes, and decreased ability to mediate an antitumor response in vivo. T lymphocytes from tumor-bearing mice expressed T cell antigen receptors that contained low amounts of CD3γ and completely lacked CD3ζ, which was replaced by the Fc ε γ-chain. Expression of the tyrosine kinases p56 lck and p59 fyn was also reduced. These changes could be the basis of immune defects in tumor-bearing hosts.

Keywords

Signal transductionBearing (navigation)Cell biologyTransduction (biophysics)T lymphocyteChemistryBiologyCancer researchImmunologyNeuroscienceImmune systemBiophysicsPhysics

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Year
1992
Type
article
Volume
258
Issue
5089
Pages
1795-1798
Citations
638
Access
Closed

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Cite This

Hiromoto Mizoguchi, John J. O’Shea, Dan L. Longo et al. (1992). Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice. Science , 258 (5089) , 1795-1798. https://doi.org/10.1126/science.1465616

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DOI
10.1126/science.1465616