Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

Keisuke Kuida; Judith A. Lippke; George Ku; Matthew W. Harding; David J. Livingston; Michael Su; Richard A. Flavell

doi:10.1126/science.7535475

Abstract

The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE -/- ) did not export IL-1β or interleukin-1α (IL-1α) after stimulation with lipopolysaccharide. Export of tumor necrosis factor-α and interleukin-6 (IL-6) from these cells was also diminished. Thymocytes from ICE -/- mice were sensitive to apoptosis induced by dexamethasone or ionizing radiation, but were resistant to apoptosis induced by Fas antibody. Despite this defect in apoptosis, ICE -/- mice proceed normally through development.

Keywords

ApoptosisProinflammatory cytokineInterleukinCytokineTumor necrosis factor alphaInterleukin 15ChemistryInterleukin 4BiologyMolecular biologyEndocrinologyImmunologyInflammationBiochemistry

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Publication Info

Year: 1995
Type: article
Volume: 267
Issue: 5206
Pages: 2000-2003
Citations: 1620
Access: Closed

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APA Style

                            
                                
                                    Keisuke Kuida, 
                                
                                    Judith A. Lippke, 
                                
                                    George Ku
                                
                                et al.
                            
                            (1995). 
                            Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme. 
                            Science
                            , 267
                            (5206)
                            , 2000-2003.
                            https://doi.org/10.1126/science.7535475
                        

Identifiers

DOI: 10.1126/science.7535475