Structure and mechanism of interleukin-lβ converting enzyme
Interleukin-1 beta converting enzyme (ICE) processes an inactive precursor to the proinflammatory cytokine, interleukin-1 beta, and may regulate programmed cell death in neurona...
Publications
4 shownAltered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
The interleukin-1β (IL-1β) converting enzyme (ICE) processes the inactive IL-1β precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE...
Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
Interleukin-1 beta converting enzyme (ICE) is composed of 10' (p10) and 20 kDa (p20) subunits, which are derived from a common 45 kDa precursor. Recent crystallographic studies ...
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Researcher Info
- h-index
- 4
- Publications
- 4
- Citations
- 4,972
- Institution
- Vertex Pharmaceuticals (United States)
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Impact Metrics
h-index
4
h-index: Number of publications with at least h citations each.