Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Keywords

MedicineInsulin resistanceAlzheimer's diseaseType 2 diabetesNeuroscienceDiseaseDiabetes mellitusCognitive scienceInsulinInternal medicineEndocrinologyPsychology

Affiliated Institutions

Related Publications

Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus

Jerrold M. Olefsky , Orville Kolterman , J A Scarlett

Resistance to the action of insulin can result from a variety of causes, including the formation of abnormal insulin or proinsulin molecules, the presence of circulating antagon...

1982 American Journal of Physiology-Endocr... 277 citations

Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome

Bo Isomaa , Peter Almgren , Jaakko Tuomilehto +5 more

OBJECTIVE—To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization (WH...

2001 Diabetes Care 4753 citations

The Metabolic Syndrome

Marc‐André Cornier , Dana Dabelea , Teri L. Hernandez +6 more

The "metabolic syndrome" (MetS) is a clustering of components that reflect overnutrition, sedentary lifestyles, and resultant excess adiposity. The MetS includes the clustering ...

2008 Endocrine Reviews 2049 citations

Association between insulin resistance and the development of cardiovascular disease

Valeska Ormazábal , Soumyalekshmi Nair , Omar Elfeky +3 more

For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid pr...

2018 Cardiovascular Diabetology 2191 citations

Exogenous Insulin Administration and Cardiovascular Risk in Non-Insulin-dependent and Insulin-dependent Diabetes Mellitus

Saul Genuth

The UGDP trial was flawed by inadequate power, insufficient separation of glycemic levels, and ignorance of smoking history as a possible confounder. In the DCCT, the number of ...

1996 Annals of Internal Medicine 88 citations

Publication Info

Year: 2018
Type: review
Volume: 14
Issue: 3
Pages: 168-181
Citations: 1382
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1382

OpenAlex

Cite This

APA Style

                            
                                
                                    Steven E. Arnold, 
                                
                                    Zoe Arvanitakis, 
                                
                                    Shannon L. Macauley
                                
                                et al.
                            
                            (2018). 
                            Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. 
                            Nature Reviews Neurology
                            , 14
                            (3)
                            , 168-181.
                            https://doi.org/10.1038/nrneurol.2017.185
                        

Identifiers

DOI: 10.1038/nrneurol.2017.185