Abstract

Abstract CD10 and MUM1 are representative B cell differentiation markers. Follicular lymphoma (FL) is usually positive for CD10 and negative for MUM1. In this study, however, we compared 22 FLs with peculiar phenotype CD10−MUM1+ with 119 typical CD10+MUM1− FLs. All CD10−MUM1+ FL patients exhibited follicular structure with follicular dendritic meshwork, and a high rate of somatic hypermutation and ongoing mutation, similar to typical FL. However, CD10−MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1− typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). Our results indicate that CD10−MUM1+ FL is different from typical FL with respect to biologic and clinical features.

Keywords

Follicular lymphomaBCL6Chromosomal translocationBiologyLymphomaPathologySomatic hypermutationInternal medicineCancer researchMedicineGerminal centerGeneB cellImmunologyGeneticsAntibody

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Publication Info

Year
2006
Type
article
Volume
109
Issue
7
Pages
3076-3079
Citations
150
Access
Closed

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Kennosuke Karube, Ying Guo, Junji Suzumiya et al. (2006). CD10−MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features. Blood , 109 (7) , 3076-3079. https://doi.org/10.1182/blood-2006-09-045989

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DOI
10.1182/blood-2006-09-045989