Abstract
Results of antimediator therapies in clinical trials in septic shock are inconclusive but suggest that the response may differ, depending on the type of microbic pathogen. The immune-mediated pathophysiologic mechanisms that underlie gram-positive sepsis and the potential interactions between the infecting microorganism and efficacy of anticytokine therapies require further investigation. Treatment strategies that explain the causative organism may be necessary for optimal use of immunoadjuvants in the future.
Keywords
SepsisMedicineImmunologySeptic shockPathogenesisImmune systemPathogenInflammationSystemic inflammatory response syndromeProinflammatory cytokinePathophysiologyIntensive care medicineInternal medicine
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Publication Info
- Year
- 1999
- Type
- review
- Volume
- 27
- Issue
- 8
- Pages
- 1608-1616
- Citations
- 270
- Access
- Closed
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Cite This
Steven M. Opal,
Jonathan Cohen
(1999).
Clinical Gram-positive sepsis.
Critical Care Medicine
, 27
(8)
, 1608-1616.
https://doi.org/10.1097/00003246-199908000-00039
Identifiers
- DOI
- 10.1097/00003246-199908000-00039