Abstract
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival. Certain cells have unique sensors, termed death receptors, on their surface. Death receptors detect the presence of extracellular death signals and, in response, they rapidly ignite the cell's intrinsic apoptosis machinery.
Keywords
Programmed cell deathReceptorCell biologyApoptosisExtracellularBiologySignal transductionMechanism (biology)CellCell surface receptorBiochemistryPhysics
MeSH Terms
AnimalsAntigensCDApoptosisHumansNeoplasmsReceptorsCell SurfaceReceptorsTNF-Related Apoptosis-Inducing LigandReceptorsTumor Necrosis FactorReceptorsTumor Necrosis FactorMember 25ReceptorsTumor Necrosis FactorType ISignal Transductionfas Receptor
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 281
- Issue
- 5381
- Pages
- 1305-1308
- Citations
- 5830
- Access
- Closed
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Cite This
Avi Ashkenazi,
Vishva M. Dixit
(1998).
Death Receptors: Signaling and Modulation.
Science
, 281
(5381)
, 1305-1308.
https://doi.org/10.1126/science.281.5381.1305
Identifiers
- DOI
- 10.1126/science.281.5381.1305
- PMID
- 9721089