Abstract

Proteomic analysis of GBM samples revealed three patterns of expression and activation of proteins in glioma-relevant signaling pathways. These three classes are comprised of roughly equal numbers showing either EGFR activation associated with amplification and mutation of the receptor, PDGF-pathway activation that is primarily ligand-driven, or loss of NF1 expression. The associated signaling activities correlating with these sentinel alterations provide insight into glioma biology and therapeutic strategies.

Keywords

Signal transductionBiologyPDGFRACancer researchNotch signaling pathwayGliomaPI3K/AKT/mTOR pathwayHES1MAPK/ERK pathwayPDGFBPDGFRBPlatelet-derived growth factor receptorCell biologyGeneticsStromal cellReceptorGeneGrowth factor

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Publication Info

Year
2009
Type
article
Volume
4
Issue
11
Pages
e7752-e7752
Citations
535
Access
Closed

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Cameron Brennan, Hiroyuki Momota, Dolores Hambardzumyan et al. (2009). Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations. PLoS ONE , 4 (11) , e7752-e7752. https://doi.org/10.1371/journal.pone.0007752

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DOI
10.1371/journal.pone.0007752