Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.

Jane Weaver-Feldhaus; Nelleke A. Gruis; Susan L. Neuhausen; Denis Le Paslier; Elisabeth Stockert; Mark H. Skolnick; Alexander Kamb

doi:10.1073/pnas.91.16.7563

Abstract

The p21 region of human chromosome 9 is thought to contain a gene (MLM) involved in genetic susceptibility to melanoma and a gene or genes that influence progression of certain other tumors. Genomic clones that span a large region in 9p21 surrounding the presumptive tumor suppressor gene(s) have been isolated. A set of sequence-tagged sites in this region has been developed. By using these markers and others previously reported, the 9p21 region has been studied by physical mapping in 84 melanoma cell lines. A putative tumor suppressor gene, perhaps MLM itself, has been localized to a region of less than 40 kb that lies proximal (centromeric) to the alpha-interferon gene cluster.

Keywords

GeneBiologySuppressorTumor suppressor geneGeneticsMelanomaGene clusterChromosomeGene mappingCarcinogenesis

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Publication Info

Year: 1994
Type: article
Volume: 91
Issue: 16
Pages: 7563-7567
Citations: 64
Access: Closed

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APA Style

                            
                                
                                    Jane Weaver-Feldhaus, 
                                
                                    Nelleke A. Gruis, 
                                
                                    Susan L. Neuhausen
                                
                                et al.
                            
                            (1994). 
                            Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.. 
                            Proceedings of the National Academy of Sciences
                            , 91
                            (16)
                            , 7563-7567.
                            https://doi.org/10.1073/pnas.91.16.7563
                        

Identifiers

DOI: 10.1073/pnas.91.16.7563