Keywords

BiologyDNA methylationMethyltransferaseMethylationRNA-Directed DNA MethylationDNA methyltransferaseDNMT1EpigenomicsGeneticsCpG siteHistone methylationMolecular biologyGeneGene expression

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The DNA methyltransferases of mammals

The biological significance of 5-methylcytosine was in doubt for many years, but is no longer. Through targeted mutagenesis in mice it has been learnt that every protein shown b...

2000 Human Molecular Genetics 1998 citations

Publication Info

Year
1999
Type
article
Volume
23
Issue
3
Pages
363-366
Citations
185
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Closed

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Frank Lyko, Bernard Ramsahoye, Helena Kashevsky et al. (1999). Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila. Nature Genetics , 23 (3) , 363-366. https://doi.org/10.1038/15551

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DOI
10.1038/15551