Timothy H. Bestor

Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence promoters, especially those associated with transposons and imprinted genes. Cytosine methylatio...

The DNA methyltransferases of mammals

The biological significance of 5-methylcytosine was in doubt for many years, but is no longer. Through targeted mutagenesis in mice it has been learnt that every protein shown b...

Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.

Creation of genomic methylation patterns

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Dnmt3L and the Establishment of Maternal Genomic Imprints

Complementary sets of genes are epigenetically silenced in male and female gametes in a process termed genomic imprinting. The Dnmt3L gene is expressed during gametogenesis at s...