Abstract
The results indicate that it is possible to map SMS reads with high accuracy and speed. Furthermore, the inferences made on the mapability of SMS reads using our combinatorial model of sequencing error are in agreement with the mapping accuracy demonstrated on simulated reads.
Keywords
DNA sequencingHybrid genome assemblyComputer scienceDeep sequencingShotgun sequencingAlignment-free sequence analysisComputational biologySingle molecule real time sequencingDNA microarraySingle cell sequencingError detection and correctionReference genomeAlgorithmData miningGenomeBiologyGeneticsSequence alignmentExome sequencingDNA sequencerDNAMutationGene
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Publication Info
- Year
- 2012
- Type
- article
- Volume
- 13
- Issue
- 1
- Pages
- 238-238
- Citations
- 1316
- Access
- Closed
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Cite This
Mark Chaisson,
Glenn Tesler
(2012).
Mapping single molecule sequencing reads using basic local alignment with successive refinement (BLASR): application and theory.
BMC Bioinformatics
, 13
(1)
, 238-238.
https://doi.org/10.1186/1471-2105-13-238
Identifiers
- DOI
- 10.1186/1471-2105-13-238