Abstract

In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a molecule already recognized as an important regulator of cell survival, inflammation and disease, was attributed an additional function: the regulation of a novel cell death pathway that came to be known as necroptosis. Subsequently, the related kinase RIPK3 and its substrate mixed-lineage kinase domain-like protein (MLKL) were also implicated in the necroptotic pathway, and links between this pathway and apoptosis were established. In this Timeline article, we outline the discoveries that have helped to identify the roles of RIPK1, RIPK3, MLKL and other regulators of necroptosis, and how they interact to determine cell fate.

Keywords

NecroptosisRIPK1Cell biologyBiologyProgrammed cell deathProtein kinase AKinaseSignal transductionCancer researchApoptosisBiochemistry

MeSH Terms

AnimalsApoptosisCaspase 8Cell DeathDisease ModelsAnimalHumansInflammasomesInflammationNecrosisProtein KinasesReceptor-Interacting Protein Serine-Threonine Kinases

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Publication Info

Year
2016
Type
review
Volume
18
Issue
2
Pages
127-136
Citations
953
Access
Closed

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Cite This

Ricardo Weinlich, Andrew Oberst, Helen M. Beere et al. (2016). Necroptosis in development, inflammation and disease. Nature Reviews Molecular Cell Biology , 18 (2) , 127-136. https://doi.org/10.1038/nrm.2016.149

Identifiers

DOI
10.1038/nrm.2016.149
PMID
27999438

Data Quality

Data completeness: 81%