Tony Hunter

A framework for advancing our understanding of cancer-associated fibroblasts

The Protein Kinase Complement of the Human Genome

We have catalogued the protein kinase complement of the human genome (the “kinome”) using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) seq...

Oncogenic kinase signalling

Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their ...

Signaling—2000 and Beyond

Evolution of protein kinase signaling from yeast to man

Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolutio...

A thousand and one protein kinases

The protein kinases of budding yeast: six score and more

The completion of the budding yeast genome sequencing project has made it possible to determine not only the total number of genes, but also the exact number of genes of a parti...