Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Christine M. Dejea; Payam Fathi; John M. Craig; Annemarie Boleij; Rahwa Taddese; Abby L. Geis; Xinqun Wu; Christina E. DeStefano Shields; Elizabeth M. Hechenbleikner; David L. Huso; Robert A. Anders; Francis M. Giardiello; Elizabeth C. Wick; Hao Wang; Shaoguang Wu; Drew M. Pardoll; Franck Housseau; Cynthia L. Sears

doi:10.1126/science.aah3648

Abstract

Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et al. examined the colonic mucosa of FAP patients. They discovered biofilms containing the carcinogenic versions of the bacterial species Escherichia coli and Bacteroides fragilis . Colon tissue from FAP patients exhibited greater expression of two bacterial genes that produce secreted oncotoxins. Studies in mice showed that specific bacteria could work together to induce colon inflammation and tumor formation. Science , this issue p. 592

Keywords

Familial adenomatous polyposisColorectal cancerMicrobiomeAdenomatous polyposis coliAdenomatous polypsMedicineBacteriaBiofilmGastroenterologyBiologyCancerPathologyInternal medicineGeneticsColonoscopy

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Publication Info

Year: 2018
Type: article
Volume: 359
Issue: 6375
Pages: 592-597
Citations: 1034
Access: Closed

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APA Style

                            
                                
                                    Christine M. Dejea, 
                                
                                    Payam Fathi, 
                                
                                    John M. Craig
                                
                                et al.
                            
                            (2018). 
                            Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. 
                            Science
                            , 359
                            (6375)
                            , 592-597.
                            https://doi.org/10.1126/science.aah3648
                        

Identifiers

DOI: 10.1126/science.aah3648