Regulation of Inhibitory Pathways of the Interleukin‐1 System

Abstract

A bstract : The IL‐1 system includes two agonists, converting enzymes, antagonists, and two receptors (R). New elements and functions in the system will be discussed, including (a) cloning of a new isoform of the receptor antagonist; (b) further analysis of the type II IL‐1‐binding molecule as a decoy R. The modulation of IL‐1R by chemotactic signals was recently investigated. It was found that chemoattractants cause rapid release of the type II decoy R from myelomonocytic cells with a t 1/2 of 30 sec. Induction of decoy R release represents an early event in the multistep process of recruitment. It may serve to block the systemic action of IL‐1 leaking from sites of inflammation, while preserving responsiveness in situ . We recently cloned the first long pentraxin, PTX3 (human and mouse, cDNA and genomic) as an IL‐1‐inducible gene. The structural and functional features of this molecule as well as initial evidence of involvement in human pathology will be discussed.

Keywords

Affiliated Institutions

• University of Brescia IT
• Mario Negri Institute for Pharmacological Research IT
• Nerviano Medical Sciences IT

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