Keywords
AngiogenesisHIF1AHypoxia (environmental)Cancer researchTranscription factorHypoxia-Inducible Factor 1Hypoxia-inducible factorsCancerBiologyCancer cellMedicineGeneBioinformaticsInternal medicineChemistryGenetics
Affiliated Institutions
Related Publications
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortalit...
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.
Hypoxia-inducible factor 1 (HIF-1) transactivates genes the products of which mediate tumor angiogenesis and glycolytic metabolism. Overexpression of the HIF-1 alpha subunit, re...
Purification and Characterization of Hypoxia-inducible Factor 1
Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatme...
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
Here we describe the cloning and characterization of a PAS domain transcription factor termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia i...
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing
HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is ta...
Publication Info
- Year
- 2003
- Type
- review
- Volume
- 3
- Issue
- 10
- Pages
- 721-732
- Citations
- 6587
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
6587
OpenAlex
Cite This
Gregg L. Semenza
(2003).
Targeting HIF-1 for cancer therapy.
Nature reviews. Cancer
, 3
(10)
, 721-732.
https://doi.org/10.1038/nrc1187
Identifiers
- DOI
- 10.1038/nrc1187