Publications
9 shownHypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin g...
Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortalit...
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
We have identified a 50-nucleotide enhancer from the human erythropoietin gene 3'-flanking sequence which can mediate a sevenfold transcriptional induction in response to hypoxi...
Purification and Characterization of Hypoxia-inducible Factor 1
Hypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatme...
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding act...
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but not in extracts from cells cultured in 20% O2. H...
Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.
Hypoxia-inducible factor 1 (HIF-1) transactivates genes the products of which mediate tumor angiogenesis and glycolytic metabolism. Overexpression of the HIF-1 alpha subunit, re...
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix protein implicated in the transcriptional activation of genes encoding erythropoietin, glycolytic en...
Frequent Co-Authors
Researcher Info
- h-index
- 9
- Publications
- 9
- Citations
- 23,783
- Institution
- Johns Hopkins Medicine
External Links
Identifiers
- ORCID
- 0000-0002-0913-211X
Impact Metrics
h-index: Number of publications with at least h citations each.