Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

2018 New England Journal of Medicine 3,775 citations

Abstract

In this international study of CAR T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma in adults, high rates of durable responses were produced with the use of tisagenlecleucel. (Funded by Novartis; JULIET ClinicalTrials.gov number, NCT02445248 .).

Keywords

MedicineCytokine release syndromeNeutropeniaInternal medicineHematopoietic stem cell transplantationDiffuse large B-cell lymphomaLymphomaRefractory (planetary science)TransplantationGastroenterologyFebrile neutropeniaRituximabClinical endpointOncologyPhases of clinical researchSalvage therapyImmunologyImmunotherapyChimeric antigen receptorChemotherapyClinical trialCancer

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Publication Info

Year
2018
Type
article
Volume
380
Issue
1
Pages
45-56
Citations
3775
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Stephen J. Schuster, Michael Bishop, Constantine S. Tam et al. (2018). Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma. New England Journal of Medicine , 380 (1) , 45-56. https://doi.org/10.1056/nejmoa1804980

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DOI
10.1056/nejmoa1804980